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Construction > Adhesion

The following information is about Adhesion.

Adhesion Defined

The degree of attachment or bonding of one substance to another.

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Off-site Adhesion Links, User Submitted

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  • Talin phosphorylatio n by Cdk5 regulates Smurf1-mediate d talin head ubiquitylation and cell migration : Article : Nature Cell Biology: The final paragraph: In migratory cells, talin is cleaved into head and rod domains by calpain. The head domain in turn binds to Smurf1 and is consequently ubiquitylated and degraded. This step, downstream of calpain, provides a more complete explanation for calpain-mediat ed focal adhesion turnover. We find that talin phosphorylatio n by Cdk5 inhibits talin head ubiquitylation and degradation, thus limiting focal adhesion turnover and stabilizing lamellipodia at the leading edges, which in turn leads to optimal rates of cell migration (Fig. 5i). Thus, our studies explain the capacity of talin proteolysis to promote focal adhesion disassembly, identify talin as an important target of Smurf1-induced ubiquitylation and degradation, and establish talin as a relevant substrate of Cdk5

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